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Niclofolan

2016-05-31 14:13:25   Click:

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【Name】Niclofolan 
【CAS NO 】10331-57 - 4
【characteristics 】this product is a yellow crystalline powder. Odourless. This product in the dissolved in acetone, chloroform, dimethylformamide, slightly soluble in ether, slightly soluble in ethanol, insoluble in water, dissolve in sodium hydroxide solution, slightly soluble in glacial acetic acid.
【pharmacological action】 (1) the pharmacodynamics Nitrate chlorophenol is China's traditional and extensive use of cattle, sheep liver piece trematode form drug resistance. Nitrate chlorophenol inhibit insect body succinate dehydrogenase, thus affect the energy metabolism of the piece trematode form and play a role of sucking insect resistance.
(2) the pharmacokinetic nitrate chlorophenol after take orally, absorbed by the intestines, but gradually the degradation reaction in the rumen. Cattle after take orally, usually 24 ~ 48 h blood to spike, but quickly fell, 5 ~ 8 days after medication, the milk juice excrete drug is still up to 0.1 mg/kg (allowable residue is 0.01 mg/kg). So the milk could not for human consumption. Nitrate chlorophenol, slowly from the animal excretion drugs after 9 days, no residue in urine in drugs.
(1) limited 】 【 sheep chlorophenol nitrate is ideal drive liver piece trematode form medicine. 3 mg/kg amount on the internal and liver piece trematode form into effective rate was 93% ~ 100%. Of immature insect body, the more the more weeks of small dosage, such as 4 mg/kg, for eight weeks of insect body effective rate was 58.4%, 100% 12 weeks of insect body; 8 mg/kg quantity, the effective rate was 92.5%, 4 weeks of insect body 6 weeks of insect body 99.7%, 99.7%, 8 weeks of insect body 16 mg/kg for 4 weeks of insect body 100% effective. Someone to a wide range of clinical trials of chlorophenol nitrate, effective dose for 12 weeks of insect body
(2) the cow chlorophenol nitrate on bovine liver shape trematode expelling effect similar to sheep liver piece trematode form. 3 mg/kg quantity of adult cattle liver piece trematode adult extermination rate was 98.74%, the calf adult extermination rate is only 76% ~ 80%. Buffalo internal and 1 ~ 3 mg/kg also has excellent curative effect, but the amount of 3 mg/kg for yak, 10 ~ 12 mg/kg of insect repellent rate was 100%, and the expulsion of the liver piece trematode form child need 16 ~ 20 mg/kg dose, but at the moment, the cow has been poisoning and no practical significance. Some clinical trials that nitrate chlorophenol before and after the transition period of trematode larvae could be some effect, because of animal body KuangMing significantly improve the medicine.
(3) the pig 3 ~ 6 mg/kg quantity internal and, on liver trematode adult expulsion rate of nearly 100%, well tolerated and animals.
【 usage and dosage 】 oral a quantity per 1 kg weight cattle 3 to 7 mg of buffalo 1-3 3-4 mg mg sheep.
Subcutaneous and intramuscular injection quantity every 1 kg weight cattle, sheep 0.6 1 mg
【 notes 】 (1) the amount of animal safer, too much cause of poisoning symptoms such as fever, difficulty breathing, smothering rate), according to the symptoms, choose Ann sodium benzoate, poison Mao Xuan glycosides, such as vitamin C treatment.
(2) residue limits standard: has not been set.
 

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