Nitazoxanide

2016-05-31 14:22:12   Click：

【Chinese】Nitazoxanide
【CAS NO 】55981-09-4
【description】white or light yellow powder, insoluble in water, slightly soluble in ethanol, soluble in dimethyl sulfoxide (NMSO) and N - dimethyl formamide (DMF), and other organic solvents.
【pharmacological action】indications nita, is a kind of nitrate thiamethoxam salicylic acid amide derivative, its actual though the mechanism of action has yet to figure out, but are thought to be associated with inhibition of pyruvic acid salt, iron REDOX proteins oxidoreductase enzyme dependence of electron transfer reaction, which is of great importance for anaerobic energy metabolism. This article except for cryptosporidium and intestinal jia first flagella worm, also for many intestinal parasites, such as bayes sporozoan, amoeba, ascaris lumbricoides, hookworm, wool first whipworm tapeworm, beef tapeworm, short film shell and fasciola hepatica were active
Applicable disease indications 】 nita (Nitazoxanide, NTZ) is a kind of four hydrogen thiazole compounds, peptides is a new type of high efficiency, broad spectrum, parasites and antibacterial and antiviral drugs. And parasitic resistance spectrum and antibacterial spectrum is albendazole, toluene of thiazole and metronidazole are widely, more other drugs also widely application field. The product of metronidazole sensitive feeling and resistant anaerobic bacteria and the activity of h. pylori is better than metronidazole.
(1) peptides: cryptosporidiosis Cryptosporidiosis is a global zoonotic parasitic diseases, the pathogen is a kind of compound door at the top of the parasitic protozoa, cryptosporidium. The disease can infect humans, pigs, cattle, sheep, birds and other animals, severe diarrhea, dehydration, thin as the main symptoms. Indications nita, as for the wonder drug for the treatment of cryptosporidiosis, confirmed by the experiment the curative effect.
Through the experiments of recent years, the indications, in the treatment of roundworm, whipworm, membrane shell tapeworm when the effect is not inferior to the specific of albendazole and praziquantel. In addition, the indications nita, to creep in intestinal nematodes, whip lash and tiny membrane shell tapeworm, sheep monie tapeworm, beef tapeworm and short film and shell of taeniasis intestinal tapeworm and part of the intestinal nematodes have effect.
1, indications, nita to unprogressive clostridium, h. pylori has strong inhibition and killing effect. Indications nita, in conjunction with omeprazole, to the eradication of helicobacter pylori has a high rate, and there will be no resistance.
【 usage and dosage 】 the water for 15 to 20 kg per gram for poultry drink freely
【 notes 】 cross allergy: this medicine may cross with for azole nita, allergy.

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