Probenecid

2016-05-27 11:41:45   Click：

[properties] white crystalline powder; Odourless and slightly bitter taste. This product is slightly soluble in ethanol or, almost insoluble in water; Dissolved in dilute sodium hydroxide solution, almost insoluble in dilute acid.
[pharmacological action] this product is a chemical synthesis of benzoic acid derivatives. Can inhibit renal tubular resorption of uric acid salt, promote the uric acid excretion, reduce the concentration of plasma uric acid salt. Can be used for chronic gout, for acute gout is invalid (because there was no analgesic and anti-inflammatory effects). And inhibit the penicillin and cephalosporin, excretion of drugs such as amino salicylic acid, and penicillin and cephalosporin used, can increase the blood drug concentration, extend its effectiveness, and can reduce the dosage. Clinical used in the treatment of gouty arthritis associated with high uric acid hematic disease. Also can be used as synergist, penicillin and cephalosporin treatment in order to improve the blood drug concentration of the drug.
"Limited" (1) inhibition of urate in proximal renal tubular resorption actively, increases the excretion of uric acid salt and reduce the concentration of blood uric acid salt,
(2) can alleviate or prevent the generation of urate nodules, reduce joint damage,
(3) may also promote the formation of the uric acid salt dissolving, anti-inflammatory, analgesic action. For the treatment of chronic gout.
【 usage and dosage 】 (1) treatment of gout and high uric acid hematic disease: oral, horses, cattle, 1.25 to 2.5 G each time, sheep, pigs, 0.5 G, 40 mg chicken, cat, dog 60 mg, twice a day.
(2) to enhance the effect of penicillin and cephalosporin: 1 by probenecid (according to the single product) :
(3) water soluble probenecid specially designed for production of soluble preparation.
【 precautions 】 (1) the adverse reactions are mild gastrointestinal reaction, drug fever, skin rash.
(2) taking the product at the same time, add sodium bicarbonate, and drink lots of water to prevent uric acid salt in urinary tract deposition, the formation of urinary calculi.
(3) the kidney function decline, the sulphonamide have allergic reactions to avoid is used a (due to the cross with sulfanilamide allergic reactions).
 

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